Resistant hypertension (RH) is characterized as a clinical condition in which the patient needs three antihypertensive medications including diuretic for uncontrolled blood pressure (BP). Treatment of RH involves improving medication adherence and correct administration. Medication administration may be the key point when the patients’ clinical conditions are not applicable for oral drug administration. Thus, comprehensive investigation of the patient is extremely important to identify the right medication, administration route, and time. In this case report, BP control was not achieved despite consulting several related medical services/departments for the patient with gastrostomy and uncontrolled RH. Thereafter, BP was gradually decreased with the intervention of the clinical pharmacists based on detailed research about the appropriateness of drug administration through percutaneous endoscopic gastrostomy (PEG) tube and timing. Drug administration via a PEG tube or feeding tube can be challenging at some points. Although drug–drug interactions can be recognized easily, potential drug–nutrient interactions should be also considered.

Keywords: Clinical nutrition, clinical pharmacy, drug administration, percutaneous endoscopic gastrostomy, resistant hypertension